Stochastic Electrotransport paper published in PNAS

Many chemical and biomedical techniques rely on slow diffusive transport because existing pressure-based methods or electrokinetic methods can incidentally damage the sample. This study introduces a novel transport concept termed stochastic electrotransport that can selectively and nondestructively expedite transport of electromobile molecules into a porous sample, such as fixed biological tissues. We use the method to rapidly transport several classes of molecules into whole mouse brains and other organs and achieve rapid clearing and staining of the entire tissue in record time without damaging the sample. Our new method may facilitate the application of various molecular techniques to large and dense tissues.