• Jian Ren, Heejin Choi, Kwanghun Chung, and Brett E. Bouma. "Label-free volumetric optical imaging of intact murine brains", Scientific Report, 2017, 7, DOI:10.1038/srep46306. View PDF
  • Magdalena Renner, Madeline A. Lancaster, Shan Bian, Heejin Choi, Taeyun Ku, Angela Peer, Kwanghun Chung, and Juergen A. Knoblich. “Self-organized developmental patterning and differentiation in cerebral organoids”, EMBO J, 2017, doi: 10.15252/embj.201694700. View PDF


  • Taeyun Ku, Justin Swaney, Jeong-Yoon Park, Alexander Albanese, Evan Murray, Jae Hun Cho, Young-Gyun Park, Vamsi Mangena, Jiapei Chen, and Kwanghun Chung. "Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues", Nature Biotechnology, 2016, doi:10.1038/nbt.3641. View PDF    Doc S1    Movie S1    Movie S2    Movie S3    Movie S4    Movie S5    Movie S6    Movie S7    Movie S8

"MAP" highlighted in: 

  1. http://news.mit.edu/2016/imaging-brain-multiple-size-scales-0725
  2. https://techcrunch.com/2016/07/26/this-new-brain-scanning-technique-is-literally-mind-expanding/
  • Alexandre Albanese, Kwanghun Chung.  "Neuroimaging:  Whole-brain imaging reaches new heights (and lengths)", eLife, 2016, 5:e, 13367.  View PDF


  • Evan Murray, Jae Hun Cho, Daniel Goodwin, Taeyun Ku, Justin Swaney, Sung-Yon Kim, Heejin Choi, Young-Gyun Park, Jeong-Yoon Park, Austin Hubbert, Margaret McCue, Sara Vassallo, Naveed Bakh, Matthew P. Frosch, Van J. Wedeeng, H. Sebastian Seung, and Kwanghun Chung.  "Simple, scalable proteomic imaging for high-dimensional profiling of intact systems", Cell, 2015, 163, 6, 1500–1514.  View PDF    Doc S1   Table S1    Movie S1    Movie S2    Movie S3    Movie S4    Movie S5    Movie S6   Doc S2

"SWITCH" highlighted in: 
  1. http://news.mit.edu/2015/protein-imaging-detailed-brain-architecture-1203
  2. Nature Methods "Optimizing probes to image cleared tissue" by Vivien Marx (2016) 
  • Sung-Yon Kim, Jae Hun Cho, Evan Murray, Naveed Bakh, Heejin Choi, Kimberly Ohn, Luzdary Ruelas, Austin Hubbert, Meg McCue, Sara L. Vassallo, Philipp J. Keller, Kwanghun Chung. "Stochastic electrotransport selectively enhances the transport of highly electromobile molecules", PNAS, 2015, 12, 46,  E6274–E6283.  View PDF    Movie S1          Movie S2    Movie S3    Movie S4    Movie S5


  • Sung-Yon Kim, Kwanghun Chung, Karl Deisseroth “Light microscopy mapping of connections in the intact brain”, Trends in Cognitive Science, 2013.  View PDF

  • Kwanghun Chung*, Karl Deisseroth*, “CLARITY for mapping the nervous system”, Nature methods, 2013.  View PDF 

  • Kwanghun Chung, Jenelle Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, Aaron Andalman, Tom J. Davidson, Kelly A. Zalocusky, Joanna Mattis, Sally Pak, Viviana Gradinaru, Hannah Bernstein, Julie Mirzabekov, Charu Ramakrishnan, and Karl Deisseroth, “Structural and molecular interrogation of intact biological systems”, Nature, 2013 (This paper was featured in the New York Times and the Guardian)  View PDF    View news article   

View news article    CLARITY Video 1    CLARITY Video 2    CLARITY Video 3    CLARITY Video 4    CLARITY Video 5

CLARITY Video 6    CLARITY Video 7    CLARITY Video 8    CLARITY Video 9    CLARITY Video 10   CLARITY Video 11

CLARITY Video 12   CLARITY Video 13   CLARITY Video 14  CLARITY Video 15  CLARITY Video 16   CLARITY Video 17


"CLARITY" highlighted in: http://news.mit.edu/2013/new-imaging-technology-can-see-you-thinking


  • Jitendra S Kanodia, Yoosik Kim, Raju Tomer, Zia Khan, Kwanghun Chung, John D. Storey, Hang Lu, Philipp Keller, and SY Shvartsman, “A computational statistics approach for estimating the spatial range of morphogen gradient”, Development, 2011, 138, 4867-4874.  View PDF

  • Kwanghun Chung*, Mei Zhan*, Jagan Srinivasan, Paul Sternberg, Emily Gong, Frank Schroeder, and Hang Lu, “Microfluidic chamber arrays for whole-organism behavior-based chemical screening”, Lab on a Chip, 2011, 11, 3689-3697.  View PDF    S1    S2    S3

  • Kwanghun Chung*, Catherine A. Rivet*, Melissa Kemp, and Hang Lu, “Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array”, Analytical Chemistry, 2011, 83, 7044-7052.  View PDF    S1    S2    S3

  • Yoosik Kim, Maria Jose Andreu, Bomyi Lim, Kwanghun Chung, Mark Terayama, Gerardo Jimenez, Celeste A. Berg, Hang Lu and Stanislav Y Shvartsman, “Gene regulation by MAPK substrate competition”, Developmental Cell, 2011, 20, 880-887.  View PDF    S1

  • Kwanghun Chung*, Yoosik Kim*, Jitendra S Kanodia, Emily Gong, SY Shvartsman, and Hang Lu, “A microfluidic array for large-scale ordering and orientation of embryos”, Nature Methods, 2011, 8, 2, 171-176.  View PDF    S1    S2    S3    S4    S5


  • Matthew Crane, Kwanghun Chung, Jeffrey Stirman, and Hang Lu, “Microfludics-enabled phenotyping, imaging, and screening of multicellular organisms”, Lab on a Chip, 2010, 21, 1509-17.  View PDF


  • Kwanghun Chung*, Hyewon Lee*, and Hang Lu, “Multiplex pressure measurement in microsystems using volume displacement of fluorescent particle suspension”, Lab on a Chip, 2009, 9, 3345-3353.  View PDF

  • Kwanghun Chung and Hang Lu, “Automated high-throughput cell microsurgery on-chip”, Lab on a Chip, 2009, 9, 2764-2766. (This paper was selected as a Hot Article in Lab on a Chip and was also featured as a Highlight in Chemical Technology.).  View PDF    Fig S1    View article

  • Kwanghun Chung*, Jaekyu Cho*, Edward Park, Victor Breedveld, and Hang Lu, “Three-dimensional In Situ Temperature Measurement in Microfluidic System Using Brownian Motion of Nanoparticles”, Analytical Chemistry, 2009, 81, 210-217.  View PDF

  • Matthew M. Crane, Kwanghun Chung, and Hang Lu, “Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system”, Lab on a Chip, 2009, 9, 38-40.  View PDF    Movie S1    Doc S1


  • Kwanghun Chung*, Matthew M. Crane*, Hang Lu, “Automated on-chip rapid microscopy, phenotyping, and sorting of C. elegans”, Nature Methods, 2008, 5, 637-643 (This paper was reviewed in a “News and Views” article in the same issue of Nature Methods and was also featured in the New York Times).  View PDF    View news article


  • Kwanghun Chung, Juhan Kim, Byung-Kwan Cho, Byoung-Joon Ko, Bum-Yeol Hwang, Byung-Gee Kim “How does dextran sulfate prevent heat induced aggregation of protein?: The mechanism and its limitation as aggregation inhibitor”, BBA-Proteins and Proteomics, 2007, 1774, 249-257.  View PDF